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Medicines and Other Substances That Can Cause Symptoms of Depression

Overview

Many medicines can cause changes in how we feel. Some can cause symptoms of depressiondepression. These include:

  • Blood pressure medicines, such as clonidine (Catapres).
  • Barbiturates. Some examples are pentobarbital (Nembutal), phenobarbital, and secobarbital (Seconal).
  • Benzodiazepines. Some examples are alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan).
  • Calcium channel blockers, such as verapamil (Calan).
  • Corticosteroids, such as prednisone.
  • Hormonal medicines. Some examples are birth control pills and hormone therapy used to treat the symptoms of menopause.
  • Isotretinoin (Claravis). This is an acne medicine.
  • Medicines used to treat Parkinson's disease or other nervous system problems, such as restless legs syndrome.
  • Medicines used to treat seizures, such as phenytoin (Dilantin).
  • Pain medicines, such as codeine or morphine.

Symptoms of depression can also be caused by the use of or withdrawal from alcohol and illegal drugs. Cocaine, amphetamines (methamphetamines, crystal meth, or crack), heroin, and marijuana can all cause symptoms of depression.

If you think that your feelings of depression may be caused by a medicine:

  • Call the doctor who prescribed the medicine. Ask if you should stop taking it or take a different one.
  • If you are taking a nonprescription medicine, stop taking it. If you feel you need to keep taking it, call your doctor. There might be a different medicine you can take.

Current as of: July 31, 2024

Author: Ignite Healthwise, LLC StaffIgnite Healthwise, LLC Staff

Clinical Review BoardClinical Review Board
All Ignite Healthwise, LLC education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of UseTerms of Use. Learn how we develop our contenthow we develop our content.

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