acetazolamide

What is the most important information I should know about acetazolamide?

What is acetazolamide?

Acetazolamide reduces the activity of a protein in your body called carbonic anhydrase. Blocking this protein can help reduce the build-up of certain fluids in the body.

Acetazolamide is used in people with certain types of glaucoma to reduce the amount of fluid in the eye, which decreases pressure inside the eye.

Acetazolamide is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. This build-up is called edema.

Acetazolamide is also used to treat certain types of seizures, and to treat or prevent altitude sickness.

Acetazolamide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking acetazolamide?

• severe liver disease, or cirrhosis;
• severe kidney disease;
• an electrolyte imbalance (such as acidosis or low levels of potassium or sodium in your blood);
• adrenal gland failure; or
• an allergy to sulfa drugs.

To make sure acetazolamide is safe for you, tell your doctor if you have:

• severe breathing problems;
• angle closure glaucoma; or
• if you also take aspirin in high doses.

How should I take acetazolamide?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Your dose of this medicine will depend on the condition you are treating. If you take acetazolamide for congestive heart failure, your doctor may tell you to skip your medication for a day. Follow your doctor's dosing instructions very carefully.

While using acetazolamide, you may need frequent blood tests.

Acetazolamide may be only part of a complete treatment program that may also include other medications. Follow your doctor's instructions very closely.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while taking acetazolamide?

What are the possible side effects of acetazolamide?

• blood in urine or stools;
• a seizure (convulsions);
• loss of movement in any part of your body;
• a blood cell disorder --sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, pale skin, feeling tired or short of breath, rapid heart rate, nosebleeds, bleeding gums;
• liver problems --nausea, upper stomach pain or swelling, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• signs of metabolic acidosis --confusion, vomiting, lack of energy, irregular heartbeats;
• signs of a kidney stone --pain in your side or lower back, blood in your urine, painful or difficult urination; or
• severe skin reaction --fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• nausea, vomiting, loss of appetite, diarrhea;
• numbness or tingling, especially in your arms and legs;
• drowsiness, confusion;
• hearing problems, ringing in your ears;
• increased urination; or
• altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetazolamide?

Other drugs may interact with acetazolamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about acetazolamide.