Edoxaban Oral Tablet (EDOXABAN - ORAL)

Instructions

If unable to swallow the tablet, crush and mix with some water or applesauce. Mix well and take immediately.

If you are giving this medicine through a tube into the stomach, ask your doctor or pharmacist for specific directions.

This medicine may be taken with or without food.

Swallow with a full glass (8 oz) of water unless your doctor gives you different instructions.

This medicine will work best if you take it at about the same time every day.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

Discard medicine mixed with food after each dose. Do not save to use later.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you forget to take a dose on time, take it as soon as you remember. If you don't remember until the next day, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Talk to your doctor before taking other medicines, including aspirins and ibuprofen containing products. Speak to your doctor about which medicines are safe to use while you are on this medicine.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

This medicine may cause serious bleeding problems in patients taking blood thinner medications. Follow your doctor's instructions carefully to monitor your blood lab tests if you are on blood thinners.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

This medicine may cause bleeding from the stomach or bowels. Stop this medicine and call your doctor right away if you have pain in the stomach, red or dark tarry stools, or vomit that looks like coffee grounds.

There is an increased risk of bleeding while on this medicine, please tell your doctor or nurse if you notice any excessive bleeding or bruising.

Do not use the medication any more than instructed.

If you drink alcohol regularly, please speak with your doctor.

Call the doctor if there are any signs of confusion or unusual changes in behavior.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

If you have had a heart attack or a stroke within the past year, talk to your doctor before using this medicine.

Do not share this medicine with anyone who has not been prescribed this medicine.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Always refill this medicine before it runs out.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• nosebleeds

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• coughing up blood or vomit that looks like coffee grounds
• fainting
• numbness or tingling in hands and feet
• severe or persistent headache
• sudden leg pain, swelling, warmth or redness
• loss of movement anywhere on the body
• shortness of breath
• bloody or dark, tarry stools
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• difficulty swallowing
• unusual or unexplained tiredness or weakness
• blood in urine
• blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.