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isosorbide dinitrate

Pronunciation: EYE soe SOR bide dye NYE trate

Brand: Dilatrate-SR, Isochron, Isordil

Isosorbide Dinitrate

slide 1 of 28, Isosorbide Dinitrate,

5 mg, round, white, imprinted with West-Ward 769

slide 1 of 28

Isosorbide Dinitrate

slide 2 of 28, Isosorbide Dinitrate,

10 mg, round, white, imprinted with W W, 771

slide 2 of 28

Isosorbide Dinitrate

slide 3 of 28, Isosorbide Dinitrate,

20 mg, round, green, imprinted with 772, W W

slide 3 of 28

Isosorbide Dinitrate

slide 4 of 28, Isosorbide Dinitrate,

30 mg, round, blue

slide 4 of 28

Isordil Titradose

slide 5 of 28, Isordil Titradose,

5 mg, round, pink, imprinted with BPI 152

slide 5 of 28

Isordil Titradose

slide 6 of 28, Isordil Titradose,

40 mg, round, green, imprinted with BPI 192

slide 6 of 28

Isosorbide Dinitrate

slide 7 of 28, Isosorbide Dinitrate,

10 mg, round, white, imprinted with GG 26

slide 7 of 28

Isosorbide Dinitrate

slide 8 of 28, Isosorbide Dinitrate,

5 mg, round, pink, imprinted with GG 259

slide 8 of 28

Isosorbide Dinitrate

slide 9 of 28, Isosorbide Dinitrate,

20 mg, round, green, imprinted with GG 227

slide 9 of 28

Isosorbide Dinitrate

slide 10 of 28, Isosorbide Dinitrate,

30 mg, round, blue, imprinted with par 009

slide 10 of 28

Isosorbide Dinitrate

slide 11 of 28, Isosorbide Dinitrate,

5 mg, round, white, imprinted with Par 020

slide 11 of 28

Isosorbide Dinitrate

slide 12 of 28, Isosorbide Dinitrate,

10 mg, round, white, imprinted with par 021

slide 12 of 28

Isosorbide Dinitrate

slide 13 of 28, Isosorbide Dinitrate,

20 mg, round, green, imprinted with par 022

slide 13 of 28

Dilatrate-SR

slide 14 of 28, Dilatrate-SR,

40 mg, capsule, pink, imprinted with AP, 0920

slide 14 of 28

Isosorbide Dinitrate Extended Release

slide 15 of 28, Isosorbide Dinitrate Extended Release,

40 mg, round, peach, imprinted with 3613 IL

slide 15 of 28

Isosorbide Dinitrate

slide 16 of 28, Isosorbide Dinitrate,

30 mg, round, blue, imprinted with WW 773

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Isordil Tembids

slide 17 of 28, Isordil Tembids,

40 mg, round, green, imprinted with WYETH 4192

slide 17 of 28

Isosorbide Dinitrate

slide 18 of 28, Isosorbide Dinitrate,

10 mg, round, white, imprinted with GG 26

slide 18 of 28

Isosorbide Dinitrate

slide 19 of 28, Isosorbide Dinitrate,

10 mg, round, white, imprinted with par 021

slide 19 of 28

Isosorbide Dinitrate

slide 20 of 28, Isosorbide Dinitrate,

20 mg, round, green, imprinted with GG 227

slide 20 of 28

Isosorbide Dinitrate

slide 21 of 28, Isosorbide Dinitrate,

30 mg, round, blue, imprinted with par 009

slide 21 of 28

Isosorbide Dinitrate

slide 22 of 28, Isosorbide Dinitrate,

10 mg, round, white, imprinted with W W, 771

slide 22 of 28

Isosorbide Dinitrate

slide 23 of 28, Isosorbide Dinitrate,

2.5 mg, round, yellow, imprinted with W1

slide 23 of 28

Isosorbide Dinitrate

slide 24 of 28, Isosorbide Dinitrate,

20 mg, round, green, imprinted with par 022

slide 24 of 28

Isosorbide Dinitrate

slide 25 of 28, Isosorbide Dinitrate,

20 mg, round, green, imprinted with 772, WW, W W

slide 25 of 28

Isosorbide Dinitrate Extended Release

slide 26 of 28, Isosorbide Dinitrate Extended Release,

40 mg, round, peach, imprinted with 3613 IL

slide 26 of 28

Isosorbide Dinitrate

slide 27 of 28, Isosorbide Dinitrate,

5 mg, round, white, imprinted with W3

slide 27 of 28

Isosorbide Dinitrate

slide 28 of 28, Isosorbide Dinitrate,

5 mg, round, white, imprinted with West-Ward 769

slide 28 of 28

What is the most important information I should know about isosorbide dinitrate?

You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide dinitrate. Taking these medicine together can cause a sudden and serious decrease in blood pressure.

Seek emergency medical attention if you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, general ill feeling).

What is isosorbide dinitrate?

Isosorbide dinitrate is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Isosorbide dinitrate is used to treat or prevent attacks of chest pain (angina).

Only the sublingual tablet should be used to treat an angina attack that has already begun.

Isosorbide dinitrate regular and extended-release tablets are used to prevent angina attacks but will not treat an angina attack.

Isosorbide dinitrate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking isosorbide dinitrate?

You should not use isosorbide dinitrate if:

you are allergic to isosorbide dinitrate, isosorbide mononitrate, or nitroglycerin; or
you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating).

You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide dinitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure.

To make sure isosorbide dinitrate is safe for you, tell your doctor if you have:

congestive heart failure;
kidney disease; or
low blood pressure.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether isosorbide dinitrate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How should I take isosorbide dinitrate?

Before using isosorbide dinitrate to treat a sudden angina attack, your doctor may want you to first use a nitroglycerin sublingual tablet. Follow your doctor's instructions about what medications to use during an attack and how much time to allow between doses.

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide dinitrate, it might stop working as well in controlling your condition.

Try to rest or stay seated when you take this medicine (may cause dizziness or fainting).

To prevent angina attacks, isosorbide dinitrate is usually taken at regular intervals.

To treat an angina attack that has already begun, use the medicine at the first sign of chest pain. Place the tablet under your tongue and allow it to dissolve slowly. Do not chew or swallow it.

You may use the sublingual tablet within 15 minutes before an activity you think might cause chest pain. Follow your doctor's instructions.

Do not crush, chew, break, or open an extended-release capsule or tablet. Swallow it whole.

Follow your doctor's dosing instructions very carefully. If your doctor changes your brand, strength, or type of isosorbide dinitrate, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of isosorbide dinitrate you receive at the pharmacy.

Seek emergency medical attention if your chest pain gets worse or lasts longer than 5 minutes, especially if you have trouble breathing or feel weak, dizzy, or nauseated, or lightheaded.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use isosorbide dinitrate.

If you take isosorbide dinitrate on a regular schedule to prevent angina, do not stop taking it suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times. Get your prescription refilled before you run out of medicine completely.

Store at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Since isosorbide dinitrate is sometimes used only when needed, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 2 hours away.

If you are using the extended-release capsule or tablet and your next dose is less than 6 hours away, skip the missed dose and use the medicine at your next regularly scheduled time.

Do not use extra medicine to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of isosorbide dinitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

What should I avoid while taking isosorbide dinitrate?

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. Alcohol may increase certain side effects of isosorbide dinitrate (dizziness, drowsiness, feeling light-headed, or fainting).

What are the possible side effects of isosorbide dinitrate?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;
worsening angina pain;
fast or slow heart rate; or
pounding heartbeats or fluttering in your chest.

Isosorbide dinitrate can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication.

Common side effects may be more likely to occur, such as:

headache; or
flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect isosorbide dinitrate?

Taking isosorbide dinitrate with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary arterial hypertension. Serious, life-threatening side effects may occur.

Tell your doctor about all your current medicines and any you start or stop using, especially:

avanafil (Stendra);
a diuretic or "water pill";
nitroglycerin;
riociguat (Adempas);
sildenafil (Viagra, Revatio);
tadalafil (Cialis, Adcirca); or
vardenafil (Levitra, Staxyn).

This list is not complete. Other drugs may interact with isosorbide dinitrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 9.01. Revision date: 3/9/2017.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this linkEnd-User License Agreement, which can be accessed by clicking on this link

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of UseTerms of Use. Learn how we develop our contenthow we develop our content.

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